San Francisco 49ers vs. Carolina Panthers projected starting lineup and depth chart for Week 12 MNF | 2025 NFL season

Week 12 action will resume on Monday when the Carolina Panthers travel to Levi’s Stadium to clash with the San Francisco 49ers. The central storyline of the matchup revolves around Christian McCaffrey, who’ll face Carolina for the first time since departing the franchise in 2022. Thanks for the submission! He will take on a Panthers team led by Bryce Young, who led them to an overtime victory over the Atlanta Falcons on Nov. 16. The quarterback threw for a career-high 448 yards and three touchdowns. 70% Win (110-25-1) 70% Win (110-25-1) 70% Win (110-25-1) Unlock Free tips from our Experts Get Picks Now Carolina (6-5) is coming off several notable upsets in recent weeks, and the team is hoping to secure a late playoff push. The 49ers (7-4) are the favorites heading into the primetime game. They’ll have a healthier offense than they’ve had all season, with McCaffrey, Brock Purdy, George Kittle, Ricky Pearsall and Jauan Jennings all expected to play. San Francisco 49ers vs. Carolina Panthers projected starting lineup for Week 12 MNF San Francisco 49ers projected starting lineup Below is the San Francisco 49ers’ projected to lineup on offense against the Carolina Panthers. Here’s a look at San Francisco’s likely defensive line. Let’s look at the 49ers’ special teams projected lineup. Carolina Panthers projected starting lineup Below is the Carolina Panthers’ projected to lineup on offense against the San Francisco 49ers. Here’s a look at Carolina’s likely defensive line. Let’s look at the Panters’ special teams projected lineup. San Francisco 49ers vs. Carolina Panthers depth chart San Francisco 49ers depth chart Here is the 49ers’ offensive depth chart. San Francisco’s defensive depth chart is listed below. Let’s look at the 49ers’ special teams depth chart. Carolina Panthers depth chart Here is the Panthers’ offensive depth chart. Carolina’s defensive depth chart is listed below. Let’s look at the Panthers’ special teams depth chart. How to watch the 49ers vs. Panthers Week 12 MNF game? TV schedule and live stream details The winner of Monday’s matchup between the Carolina Panthers and the San Francisco 49ers will solidify its position in the NFC playoff picture. The Week 12 game will start at 8: 15 p. m. ET on ESPN, with commentary from Joe Buck (play-by-play) and Troy Aikman (color analyst). Laura Rutledge and Lisa Salters will report from the sidelines. Fans can also stream the game on ESPN+, NFL+ and FuboTV. Game info: Date and time: Monday, Nov. 24 at 8: 15 p. m. ET Location: Levi’s Stadium in Santa Clara, California TV: ESPN Announcers: Joe Buck, Troy Aikman, Lisa Salters, Laura Rutledge Live streaming: FuboTV, Hulu plus Live TV, ESPN+, NFL+.
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